Which aromatase inhibitor has less side effects?

Anastrozole or letrozole therapy was associated with decreased odds of musculoskeletal side effects, as compared to exemestane use (p = . 012, OR 0.82, 95% CI 0.70–0.95 and OR 0.79, 95% CI 0.67–0.92, respectively).

Which estrogen inhibitor has the least side effects?

Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer.

Which has less side effects Femara or Arimidex?

There were fewer side effects overall on Femara (43% for Novartis’ medicine vs 65% for Arimidex; p=0.02), with significantly fewer cases of lethargy (8% vs 19%; p=0.007), headache (5% vs 14%; p=0.05), joint pain (3% vs 11%; p=0.025), abdominal discomfort (3% vs 11%; p=0.025), nausea (10% vs 21%; p=0.021) and poor appetite …

Which has less side effects anastrozole or letrozole?

Nearly 80% of patients reported one or more side effects with either agent. No differences in frequency, grade, or range of side effects were seen between drugs. Of 160 patients, 49 (30.6%) preferred letrozole, 57 (35.6%) preferred anastrozole, and 54 (33.8%) had no preference (P = 0.26, Pearson’s Chi-squared test).