What determines whether a specific tissue or organ responds to a particular hormone?
What determines whether a particular cell is able to respond to a hormone? the location of the cell. the presence of a specific hormone receptor. the structure of the hormone. the gland that releases the hormone.
How do target cells recognize specific hormones?
The “target” cells for a particular hormone have receptors, either on the cell membrane, or the case of lipid soluble hormones that can pass through the membrane, inside the cell. Only the cells that have the special receptors for that hormone will respond to exposure.
Is a molecule that binds a specific hormone?
A hormone receptor is a molecule that binds to a specific hormone. Receptors for peptide hormones tend to be found on the plasma membrane of cells, whereas receptors for lipid-soluble hormones are usually found within the cytoplasm.
What determines whether a hormone binds to a binding protein?
The number of receptors that respond to a hormone determines the cell’s sensitivity to that hormone and the resulting cellular response. … The hormone binds to the receptor protein, resulting in the activation of a signal transduction mechanism that ultimately leads to cell type-specific responses.
Which hormones have membrane bound receptors?
Protein and peptide hormones, catecholamines like epinephrine, and eicosanoids such as prostaglandins find their receptors decorating the plasma membrane of target cells.
What are 3 factors that determine target cell activation by the hormone receptor interaction?
- Target cells are cells that are receptive to a secreted hormone.
- Target cell activation is. dependent on three factors; the hormone levels in the blood, the receptor levels on the target cell, and hormone–receptor affinity.
What binds to intracellular receptors?
Intracellular receptors require ligands that are membrane permeable and include receptors for organic compound hormones, lipophilic vitamins, and small molecules such as nitric oxide and hydrogen peroxide.
Do organic compounds bind to intracellular receptors?
The organic compound hormones pass through the plasma membrane of a target cell and adhere to intracellular receptors residing in the cytoplasm or in the nucleus. The cell signaling pathways induced by the organic compound hormones regulate specific genes on the cell’s DNA.
Which hormone binds to the receptor site on the surface of a target cell?
Amino acid derivatives, such as epinephrine, are water-soluble molecules derived from amino acids (the building blocks of protein). These hormones are stored in endocrine cells until needed. They act by binding to protein receptors on the outside surface of the cell.
Do peptide hormones bind to intracellular receptors?
Receptors for peptide hormones tend to be cell surface receptors built into the plasma membrane of cells and are thus referred to as trans membrane receptors. … Receptors for organic compound hormones are usually found within the cytoplasm and are referred to as intracellular or nuclear receptors, such as testosterone.
Which molecules bind to receptors that have intracellular tyrosine kinase domains?
Which molecules bind t0 receptors that have intracellular tyrosine kinase domains? epinephrine epidermal growth factor (EGF) insulin calcium ion cAMP Ras.
Do organic compound hormones bind to cell-surface receptors?
Recent studies suggest that organic compound hormones use receptors on cellular membranes both to gain access to the intracellular compartment and to modulate cellular functions. These interactions with cell-surface receptors have important physiological consequences.
Does epinephrine have intracellular receptors?
In this way, nothing passes through the cell membrane; the hormone that binds at the surface remains at the surface of the cell while the intracellular product remains inside the cell. … The amino acid-derived hormones epinephrine and norepinephrine bind to beta-adrenergic receptors on the plasma membrane of cells.
Is epinephrine a lipid soluble hormone?
Epinephrine mediates the short term response to stress, cortisol mediates the long term responses. Cortisol is a water soluble membrane; epinephrine is lipid soluble.
Does cortisol bind to intracellular receptors?
Both cortisol and aldosterone exert their effects after uptake of free hormone from the circulation and binding to intracellular receptors; these are termed, respectively, the glucocorticoid receptor (GR, encoded by NR3C1) and the mineralocorticoid receptor (MR, encoded by NR3C2).
Does testosterone bind to intracellular receptors?
Testosterone acts on cells through intracellular transcription-regulating androgen receptors (ARs). … Binding sites for testosterone are detectable on the surface of intact IC-21 cells, which become selectively internalized independent on caveolae and clathrin-coated vesicles upon agonist stimulation.
Where is intracellular receptor?
Intracellular receptors are receptor proteins found on the inside of the cell, typically in the cytoplasm or nucleus.
Which of the following hormones interact with intracellular receptors except?
GH, Oxytocin, ADH, ANF, Aldosterone, Cortisol, Thyroxin, Epinephrine, Estradiol, GnRH, and Progesterone.