Which prefix means pain?

The prefix alters the meaning of the medical term.

3 Prefix.
PREFIX MEANING EXAMPLE OF USE IN MEDICAL TERMS
dys- painful, abnormal, difficult, laboured dysphagia

Which prefix suffix or root word means pain?

-algia
A prefix comes at the beginning of the root word and alters the word meaning.

Root Words, Prefixes and Suffixes Used in Dental Terminology.
Prefix/Suffix Definition Example
-algia pain odontALGIA = tooth pain
-a without Acellular = having no cells
arth- joint ARTHOscope=an instrument to see inside a joint