Which of the following agents is bacteriostatic in action?

[1][2][3][4] The following classes and specific antimicrobials are generally bacteriostatic: tetracyclines, macrolides, clindamycin, trimethoprim/sulfamethoxazole, linezolid, and chloramphenicol.

Which of the following antibiotics would cause misreading of mRNA?

4.6 Aminoglycosides

Aminoglycosides are potent bactericidal antibiotics that act by inhibiting bacterial protein synthesis, thereby binding bacterial 30S or 50S ribosomal subunit, inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site, and also causing misreading of mRNA.

What are the key targets of bacteriostatic drugs?

Antibacterial drugs can be either bacteriostatic or bactericidal in their interactions with target bacteria. Bacteriostatic drugs cause a reversible inhibition of growth, with bacterial growth restarting after elimination of the medicine. By contrast, bactericidal drugs eliminate their target bacteria.

Which of the following organisms would most likely be sensitive to a natural penicillin?

The natural penicillins have activity against non-beta-lactamase producing gram-positive cocci, including viridans streptococci, group A streptococci, Streptococcus pneumoniae, and anaerobic streptococcus (Peptostreptococcus, Peptococcus sp.). Enterococcus sp. is most susceptible to the natural penicillins.

Is streptomycin a broad spectrum antibiotic that binds to ribosomes?

The aminoglycosides, which include drugs such as streptomycin, gentamicin, neomycin, and kanamycin, are potent broad-spectrum antibacterials.

What do antimicrobial peptides do?

Antimicrobial peptides inhibit cell division by inhibiting DNA replication and DNA damage response (SOS response), blocking the cell cycle or causing the failure of chromosome separation (Lutkenhaus, 1990).

Is streptomycin bacteriostatic or bactericidal?

They are bactericidal compounds, and some, notably gentamicin and tobramycin, exhibit good activity against Ps. aeruginosa. Such compounds have been used widely, often in combination with β-lactam antibiotics, with which they interact synergistically, in the ‘blind’ treatment of sepsis in immunocompromised patients.

Is vancomycin bacteriostatic or bactericidal?

While vancomycin is bactericidal against all susceptible Gram-positive pathogens it exerts only bacteriostatic activity against enterococci and needs to be combined with another agent, usually an aminoglycoside, to achieve bactericidal activity.

Is gentamicin bacteriostatic or bactericidal?

Like other aminoglycosides, gentamicin is thought to act by binding to bacterial ribosomes and inhibiting protein synthesis. Nevertheless, gentamicin is considered bacteriocidal as well as bacteriostatic.

Is neomycin bactericidal or bacteriostatic?

Neomycin has a strong bacteriostatic and bactericidal effect upon various bacteria, including streptomycin-resistant strains. Resistance to neomycin develops more slowly than resistance to streptomycin, although no absolute resistance, similar to that against streptomycin, has been obtained.

Is ethambutol bacteriostatic or bactericidal?

Ethambutol is a medication used in the management and treatment of tuberculosis. It is a bacteriostatic medicine that inhibits cell wall synthesis.

Is amoxicillin bactericidal or bacteriostatic?

As a beta-lactam antibiotic, amoxicillin is mainly bactericidal. Inhibits third and final stage of bacterial cell wall synthesis by preferentially binding to specific PBPs located inside the bacterial cell wall.

Is aminoglycoside bactericidal or bacteriostatic?

Aminoglycosides are bactericidal against these organisms and the use of bacteriostatic agents, such as doxycycline or chloramphenicol has led to treatment failures (Dennis et al.

Is streptomycin an aminoglycoside?

Streptomycin is the first discovered aminoglycoside antibiotic, originally isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis. It has additional activity against several aerobic gram-negative bacteria.

What medicine is a fluoroquinolone?

FDA-approved fluoroquinolones include levofloxacin (Levaquin), ciprofloxacin (Cipro), ciprofloxacin extended-release tablets, moxifloxacin (Avelox), ofloxacin, gemifloxacin (Factive) and delafloxacin (Baxdela).

What is bacteriostatic and bactericidal?

Definition of Bacteriostatic/Bactericidal Activity. The definitions of “bacteriostatic” and “bactericidal” appear to be straightforward: “bacteriostatic” means that the agent prevents the growth of bacteria (i.e., it keeps them in the stationary phase of growth), and “bactericidal” means that it kills bacteria.

Why are tetracyclines bacteriostatic?

Tetracyclines act by interfering with the ability of a bacterium to produce certain vital proteins; thus, they are inhibitors of growth (bacteriostatic) rather than killers of the infectious agent (bacteriocidal) and are effective only against multiplying microorganisms.

What are bactericidal drugs?

Bactericidal antibiotics kill bacteria; bacteriostatic antibiotics slow their growth or reproduction. Bactericidal antibiotics that inhibit cell wall synthesis: the beta-lactam antibiotics (penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems) and vancomycin.